Abstract:

Objective To explore the correlations between VEGF expression and MVD level with the clinical characteristics and the prognosis in peripheral T-cell lymphoma（PTCL）. Methods The VEGF expression and MVD level were detected by immunohistochemical staining in pretreatment biopsies of 47 patients. The correlations between VEGF expression and MVD level with the clinical characteristics and prognosis were analyzed by using the SPSS 19.0 software. Results The positive expression rate of VEGF in PTCL tissues was 93.6％（44／47） and overexpressed rate was 55.3％（26／47）. The MVD value was （97.99±48.45）／mm²， and there were 24 cases with highlevel MVD. VEGF expression and MVD level had positive correlation （r=0.329， P=0.024）. VEGF was correlated with the clinical stage， bone marrow involvement， IPI score and ECOG score， and MVD was only correlated with clinical stage （P=0.028）. The 5-year overall survival rate and 5-year progress free survival rate of VEGF highly-expressed patients were 11.5％ and 11.5％， which were significantly lower than those in lowly-expressed patients（P＜0.05）. The 5-year overall survival rate and 5-year progress free survival rate of patients with high MVD level were 20.8％ and 8.3％， which were significantly lower than those in patients with low MVD level （P＜0.05）. Log-rank test showed VEGF， MVD， clinical stage， IPI score， bone marrow involvement and B symptoms were prognosis factors of PTCL. Conclusion Both VEGF expression and MVD level were elevated in PTCL tissues. Besides， the expression of VEGF and the level of MVD were correlated with the tumor invasion， therapeutic effects and the prognosis of PTCL.