Abstract:

Tumor microenvironment is a critical component of cancer development and progression， in which there are microRNAs that can entrance into target cells， serve as oncogenes and tumor suppressor genes， and negatively regulate the expression and function of associated target genes， finally change the constitution of tumor microenvironment. MicroRNAs play a critical role in cancer invasion and metastasis. Therefore， microRNAs have been an attractive prospect in cancer diagnosis and treatment.