奥沙利铂联合吉西他滨治疗晚期胆道系统肿瘤的临床观察

临床肿瘤学杂志

奥沙利铂联合吉西他滨治疗晚期胆道系统肿瘤的临床观察

马蕾¹，金钟²，柳江¹

1 新疆自治区人民医院肿瘤内科 2 新疆医科大学第一附属医院消化血管外科中心

收稿日期:2011-12-18 修回日期:2012-03-23 出版日期:2012-09-29 发布日期:2012-09-29
通讯作者: 柳江

Clinical observation of oxaliplatin plus gemcitabine in the treatment of advanced biliary tract carcinoma

Received:2011-12-18 Revised:2012-03-23 Online:2012-09-29 Published:2012-09-29

摘要/Abstract

摘要： 目的观察奥沙利铂联合吉西他滨治疗晚期胆道系统肿瘤的疗效及不良反应。
方法收集2008年1月至2011年3月均经影像和病理组织学确诊的晚期胆道系统肿瘤38例，具体用药方案：奥沙利铂85mg/m²静滴2h，d₁；吉西他滨835 mg/m2静滴30min，d^₁、d₈，21天为1周期。化疗2个周期评价疗效，并记录不良反应。
结果 38例均可评价疗效，获CR 1例，PR 7例，有效率（RR）为21.1%(8/38)。主要不良反应包括骨髓抑制、外周神经毒性及恶心呕吐，均未出现重度不良反应。
结论奥沙利铂联合吉西他滨治疗晚期胆道系统肿瘤患者的近期疗效较好，不良反应可以耐受，值得深入研究。

Abstract: Objective To evaluate the efficacy and toxicity of oxaliplatin plus gemcitabine in the treatment of advanced biliary tract carcinoma.
Methods Thirtyeight patients with advanced biliary tract carcinoma diagnosed by imageology and histopathology were treated with oxaliplatin 85 mg/m² iv 2h, d₁, gemcitabine 835 mg/m²iv 30min, d₁ and d₈. The regimen was repeated every 21 days and at least two cycles. The evaluation was performed after the chemotherapy for two cycles.
ResultsThirty-eight patients were evaluable for objective response rate. Complete remission (CR) was observed in 1 case and PR in 7 cases, and the objective response rate was 21.1 % (8/38).The main side-effects were myelosuppression, neuro-sensory toxicity and nausea /vomiting. There were no any death events during treatment.
Conclusion Oxaliplatin plus gemcitabine in the treatment of advanced biliary tract carcinoma is effective and tolerable. It is worth of studying in the future.

马蕾¹，金钟²，柳江¹. 奥沙利铂联合吉西他滨治疗晚期胆道系统肿瘤的临床观察[J]. 临床肿瘤学杂志, 2012, 17(9): 853-.

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