Abstract: Objective To explore the clinical characteristics，diagnosis and prognosis of large cell lung cancer（LCLC）. Methods A retrospective study was performed on the clinical records of 109 patients with LCLC from Shanghai Pulmonary Hospital. The clinical manifestatons and imaging features of the 109 patients were observed，and the relationship between clinical characteristics and prognosis were analyzed. Results There were 92 males and 17 females，and the mean age was 58 years. There were 2 patients at stageⅠA，30 at stage ⅠB，4 at stage ⅡA，16 at stage ⅡB，24 at stage ⅢA，11 at stage ⅢB and 22 at stage Ⅳ when the diagnosis was confirmed. The main clinical symptoms were cough，haemoptysis and chest pain. The imaging features were mainly peripheral type. The median survival of 109 patients was 17.9 months, and 1-, 2- and 3-year survival rates were 66.1%, 25.7% and 13.8%. The median survival of N0 and N1 were 23.7 months and 19.2 months，which were longer than those of N2 and N3 patients（12.8 months and 10.1 months），with statistical differences（P＜0.05）. There were significant differences between the survival of N2 and N3 patients（P＜0.05）.The median survival was 20.9 months and 11.5 months for stage Ⅰ-ⅢA and ⅢB-Ⅳ（P＜0.01）. The smoking index had no influence on survival. Conclusion The TNM staging and lymph node metastasis of LCLC are important factors influencing survival.