Abstract: Small cell lung cancer（SCLC）is a highly aggressive tumor and characterized by relapse and metastasis after highly effctive chemotherapy，which may be due at least in part to the existence of cancer stem cells（CSCs）. CSCs are known as the source of origin，progression，drug resistance，recurrence and metastasis in malignant tumors. CSCs use many of the same signaling pathways that are found in normal stem cells，such as Hedgehog, Notch and Wnt. The role that embryonic signaling pathways plays in the function of CSCs in SCLC，the development of new antiCSCs signaling pathways therapeutic agents，and the complexity of potential CSC signaling crosstalk are described in this review.