Abstract: Objective To explore the features of the clinicopathology and prognosis for female peritoneal malignant mesothelioma（FPMM）. Methods The clinical data and followed up results of 13 cases FPMM were collected and the tumor tissues were studied in histopathology and immunohistochemistry（IHC）. The 5 cases of metastatic poorly differentiated serous carcinomas of ovarian（MPDOSC） and 5 cases of female metastatic poorly differentiated colorectal carcinomas（MPDCC） were studied as contrast. Results Eight cases tumors occurred in pelvic cavity，5 cases occurred in peritonium. All the 13 cases were operated and carried out chemotherapy. There were 12 epithelioid patterns and 1 biopolar pattern in FPMM. The cubic or low columnar tumor cells were covered on tubules or slender and irregular papillae，or polygonal cells were arrayed in solid sheets. The size of the tumor cells with abundant and eosinophilic cytoplasm were similar， nuclear／cytoplasmic area ratio were equal. The nuclei located in center and showed well distributed fine chromatin with a light atypical and a few mitosis. Among the epithelioid tumor cells， there were dispersive giant cells or multinucleations. There was one biphasic differentiation and no sarcomatoid patten. The histological patterns of MPDOSC and MPDCC may be similar to FPMM， but the anaplasia of carcinoma cells was more outstanding. The IHC showed that P-CK， Vimentin，Calretinin were positive and CEA were negative in FPMM. CK7，CA125，p53 were positive in MPDOSC and CK20，CA19-9，CEA were positive in MPDCC. The positive index of Ki-67 was very high in 3 kinds of tumors. Twelve cases were followed up for 6-28 months. Ten cases died and 2 cases survived. The average survival was 14.8±7.8 months. However，the average survival was 10.2±3.7 months in MPDOSC and 6.9±2.1 months in MPDCC respectively. Conclusion The chief sites of FPMM were pelvic cavity. The epithlioid FPMM had their characteristics in histopathology. The IHC phenotype including positive and negative are needed to differential diagnosis. Some FPMM patients can survive longer，so they should be treated positively.