Abstract: Tumor targeted drugs possess distinct effect of targeted antitumor， which have played an important role in recent clinical therapy and displayed satisfactory prospect.With the continuous enlargement of application range of targeted drugs， interstitial lung disease associated with them is reported more and more frequently. The pathogenesis and standardized treatment guidelines of interstitial lung disease associated with targeted drugs remain unknown. Immediate withdrawal of tumor targeted drugs， intravenous corticosteroid hormones and oxygen therapy is current recommended management.