Abstract: Ovarian cancer is the leading cause of death among gynecologic malignancies. Due to the hidden onset and the lack of diagnostic tools for early detection， about 70％ of patients are detected at a progressed stage of disease， while 60％-70％ of patients with ovarian cancer relapse or die within 5 years after diagnosis. The key to improve survival is early diagnosis and early treatment. Tumor markers have significant values in early diagnosis， monitoring and therapeutic evaluation of malignant tumors. Many researchers have done tons of researches on novel tumor markers human epididymis secretory protein 4（HE4）， carbohydrate antigen 125（CA125） and risk of ovarian malignancy algorithm in the diagnosis， differential diagnosis and prognosis of ovarian cancer recently. The present article is a review of those studies.