Objective To explore the transfer process and the short-term of radiotherapy in classic Kaposi’s sarcoma. Methods In a retrospective analysis of 51 cases with classic Kaposi’s sarcoma confirmed by pathology，the distribution characteristics of tumor，radiation treatment outcomes and the short-term curative effect were investigated. Results Classic Kaposi’s sarcoma of Xinjiang province was located in the distal limb. There were 22 （43.1％） patients with both upper- and lower-extremity lesions，16 （31.4％） patients with lower-extremity lesions and 13 （25.5％） patients with both upper-extremity lesions. The development of outcome changes during the radiation treatment could be divided into 5 stages：the period of pigmentation，local swelling， decay，scabby and healing. The effective rate of radiation treatment was 96.1％. Conclusion Radiation therapy is an effective local treatment for classic Kaposi’s sarcoma，but the development process is different from skin cancer and possesses relatively unique evolutionary process.