To evaluate the effects of traditional Chinese medicine Sanhuang kangyanghua decoction on the oxidative stress related serological markers, clinical symptoms and the inhibition of angiogenesis for breast cancer patients. Methods Thirty breast cancer patients were randomly assigned to experimental and control groups (n=15). 100 ml of saline was orally administrated twice per day for each patient in control group besides the basic treatment, whereas 100 ml of Sanhuang kangyanghua decoction was orally taken for the experimental group. The levels of nitric oxide (NO) and superoxide dismutase (SOD) in serum were measured at 1d before operation and postoperatively at 12h and 7d. The levels of TNF (tumor necrosis factor)-α, IL (interleukin)-6 and VEGF (vascular endothelial growth factor) in the serum were detected at 1d before operation and postoperatively at 6, 12, 24 and 48h. Meanwhile, the sores of the symptoms caused by oxidative stress were recorded. Results Compared to the Control group, the NO level decreased and SOD level increased on 7d postoperatively in experimental group. The levels of TNF-α, IL-6 and VEGF of Experimental group were lower than those of control group within 12 to 24h postoperatively (P＜0.05). At the same time, the sores of the symptoms caused by oxidative stress significantly decreased at 24h postoperatively. Conclusion It can reduce the oxidative stress of breast cancer patients during the perioperative period with the traditional Chinese medicine Sanhuang kanguanghua decoction by its antioxidative and anti-angiogenesis effects, beneficial for the recovery and anti-metastasis for such patients.