Objective To evaluate the clinical effect and value of CT-guided percutaneous microwave ablation therapy（PMAT） for lung cancer without surgery treatment. Methods Twenty-three patients with peripheral lung cancer were treated with local anesthesia by CT-guided PMAT. There were 31 lesions in 23 patients. The microwave energy was 50-70W at a frequency of 2450MHz. The treatment was conducted by using single or two points’ablation emission according to the size and shape of tumor. Results Operations were completed in 23 patients. The average operating time was 8min（range:5-12）. After microwave ablation，lower density in the ablated area was observed by CT with lower CT values. CT value was 52.60Hu before treatment，while it reduced to 26.12Hu after treatment. There were 6 patients with complete remission，12 cases with partial remission，3 cases with stable，2 cases with progress and effective rate of 78.3％. Related complications was observed including pneumothorax in 3 cases， pleural effusion in 2 cases and 15 cases with fever. No needle track implantation was observed. The mean progression free survival was 14.6months. The 1-，2-year survival rates were 91.3％ and 82.6％. Conclusion PMAT is a minimally invasive，safe treatment and effective for lung cancer. It can improve the quality of life，prolong the survival of patients and improve the survival rate.