Abstract: Angiogenesis is the basis of tumor metastasis，while neovasularization is the indispensable condition for tumor recurrence and metastasis. Vascular endothelial growth factor（VEGF） and its receptor（VEGFR） are important regulatory factors in formation of tumor blood vessels. The VEGF／VEGFR signal pathway inhibitors have been successfully applied to clinical，but only some patients can benefit from them. If we can explore reliable predictive indicators for response to VEGF／VEGFR signal pathway inhibitors，it will give patients much more clinical benefits. In this paper，we review the progress in predictive markers for response to VEGF／VEGFR signal pathway inhibitors.