临床肿瘤学杂志

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下咽癌调强放疗的疗效分析及对喉咽功能的影响

陈震章,黄生富1,姜雪松,朱向帜,周益琴,刘菊英,何侠,张宜勤   

  1. 210009 南京 江苏省肿瘤医院放疗科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-11-30 发布日期:2013-11-30

Clinical outcome of intensity-modulated radiotherapy for hypopharyngeal carcinoma and influences on hypopharyngeal function

CHEN Zhenzhang,HUANG Shengfu,ZHU Xiangzhi,JIANG Xuesong,ZHOU Yiqin,LIU Juying,GUO Wenjie,HE Xia,ZHANG Yiqin   

  1. Department of radiotherapy,Jiangsu Tumor Hospital,Nanjing 210009,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2013-11-30 Published:2013-11-30

摘要: 目的 探讨无远处转移下咽癌患者调强放疗(IMRT)的疗效,并观察IMRT后患者的喉咽功能情况。方法 回顾性分析本院2007年4月至2012年10月收治的35例无远处转移下咽癌,均采用IMRT,原发灶大体肿瘤靶区(GTV)及颈部转移淋巴结GTV2的放疗处方剂量为66~70Gy。4例行单纯放疗,31例行放化联合治疗。随访患者的复发、生存(无病生存率及总生存率)及喉咽功能情况。结果 随访5~59个月(中位16个月),9例局部区域复发,3例远处转移。全组2年局部区域控制率、2年无病生存率和2年生存率分别为71.9%、66.1%和55.6%。13例死亡患者中有7例死于局部区域复发,3例死于远处转移。12例生存超过2年的患者中91.7%喉咽功能保留较好。结论 IMRT可提高下咽癌患者的局部区域控制率,且能较好保留喉咽功能,但局部区域复发仍是其治疗失败的主要原因。

Abstract: Objective To explore clinical outcomes of intensity-modulated radiotherapy(IMRT)for hypopharyngeal carcinoma without distant metastasis,and the hypopharyngeal function after radiotherapy. Methods Thirty-five cases were retrospectively reviewed from April 2007 to October 2012. All patients received radical IMRT with or without chemotherapy. The prescribed dose for gross tumor volume(GTV)and GTV2 was 66-70Gy. Results All patients were followed up. The median follow-up time was 16 months(range 5-59 months). Locoregional recurrence occurred in 9 cases, and distant metastasis was observed in 3 cases. The rates of 2-year locoregional control,2-year disease free survival and 2-year overall survival were 71.9%,66.1% and 55.6%, respectively. Seven of 13 patients died of locoregional recurrence, 3 of distant metastasis. The 2-year functional laryngeal rate was 91.7%. Conclusion IMRT can improve the locoregional tumor control rate and retain the hypopharyngeal functions for patients with hypopharyngeal carcinoma. However,locoregional recurrence is the main reason for treatment failure.

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