临床肿瘤学杂志

• 论著 • 上一篇    下一篇

WT1和β-catenin蛋白在非小细胞肺癌中的表达及意义

周峰,茅国新

  

  1. 盐城市第一人民医院肿瘤内科
  • 收稿日期:2013-06-27 修回日期:2013-08-19 出版日期:2013-12-31 发布日期:2013-12-31
  • 通讯作者: 茅国新

Expressions of WT1 and β-catenin protein in nonsmall cell lung cancer and their significance

ZHOU Feng,MAO Guoxin   

  1. Department of Medical Oncology,the First People's Hospital of Yancheng
  • Received:2013-06-27 Revised:2013-08-19 Online:2013-12-31 Published:2013-12-31
  • Contact: MAO Guoxin

摘要: 目的 探讨肾母细胞瘤基因1(WT1)和β-链蛋白(βcatenin)在非小细胞肺癌(NSCLC)组织中的表达情况,分析两者与临床病理特征的关系以及两者表达的相关性。
方法采用免疫组化En Vision二步法检测WT1和βcatenin蛋白在48例NSCLC组织中的表达情况,以20例癌旁组织作对照。结果 WT1蛋白在NSCLC和癌旁组织中的阳性表达率分别为62.5%和10.0%(P<0.05),β-catenin蛋白在NSCLC和癌旁组织中的异常表达率分别为72.9%和15.0%(P<0.05)。WT1蛋白表达与淋巴结转移有关,而与性别、年龄、肿块直径、病理类型、组织分化和pTNM分期均无关(P>0.05);β-catenin蛋白异常表达与组织分化有关(P<0.05),而与性别、年龄、肿块直径、pTNM分期、淋巴结转移和病理类型均无关(P>0.05)。NSCLC中WT1蛋白与β-catenin蛋白表达呈正相关(r=0.331,P<0.05)。结论 WT1和β-catenin蛋白可能与NSCLC的发生、发展有关。

Abstract: Objective To investigate the expressions of Wilms tumor 1 (WT1) and βcatenin protein in nonsmall cell lung cancer (NSCLC), and analyze their relationship with clinicopathological characteristics and the correlation between the two proteins. Methods A total of 48 paraffin-embedded tissue samples from NSCLC patients were stained by En Vision two steps method to evaluate the expressions of WT1 and β-catenin protein, and 20 adjacent normal tissues were collected as control. Results The positive rate of WT1 protein was 62.5% in NSCLC, higher than 10.0% in adjacent normal lung tissue (P<0.05). The aberrant expression rate of β-catenin protein was 72.9% in NSCLC, higher than 15.0% in adjacent normal lung tissue (P<0.05). The expression of WT1 protein was related to the status of lymph node metastasis(P<0.05), but not with gender, age, tumor diameter, pathological types, histological differentiation or pTNM staging(P>0.05). There was significant difference between βcatenin protein aberrant expression and histological differentiation(P<0.05), while no differences were found in gender, age, tumor diameter, pathological types, status of lymph node metastasis or pTNM staging(P>0.05). WT1 protein was positively related to β-catenin protein in NSCLC(r=0.331,P<0.05).
Conclusion The expressions of WT1 protein and β-catenin protein may be correlated to the occurrence and development of NSCLC.

No related articles found!
Viewed
Full text
208
HTML PDF
Just accepted Online first Issue Just accepted Online first Issue
0 0 0 0 0 208

  From Others local
  Times 14 194
  Rate 7% 93%

Abstract
76
Just accepted Online first Issue
0 0 76
  From Others
  Times 76
  Rate 100%

Cited

Web of Science  Crossref   ScienceDirect  Search for Citations in Google Scholar >>
 
This page requires you have already subscribed to WoS.
  Shared   
  Discussed   
No Suggested Reading articles found!