Abstract:

Objective To detect the expression of metastasisassociatedgene 1（MTA1） protein in tissues of small cell lung cancer（SCLC） and explore the role of MTA1 in metastasis， prognosis and chemotherapy sensitivity of SCLC. Methods The expression of MTA1 was detected in 52 non-distal metastatic SCLC tissues by immunohistochemical staining. The results were divided into low-level expression（≤6） and high-level expression（＞6） according to the immunohistochemical staining counting method. The relationships between expression of MTA1 and clinicopathological characteristics， efficacy of EP regimen（etoposide 100mg／m2 iv， d1d5；cisplatin 60mg／m2 iv d1； 3-week cycle for 4-6 cycles） and prognosis were investigated. Results Thirty-seven SCLC tissues were found of high-level MTA1 expression（71.2％）， while MTA1 was expressed at a low-level in all 18 adjacent tissues. There were significant correlations between the expression of MTA1 and tumor size， TNM stage， lymph node metastasis and vascular invasion（P＜0.05）. No significant correlation existed between the expression of MTA1 and gender， age， VALG stage and tumor sites（P＞0.05）. The low-level expression group was more sensitive to EP chemotherapy than the high-level expression group（80.0％ vs. 54.1％， P=0.020）. The median progression-free survival and overall survival of the low.level expression group were superior to those of the high-level expression group（20 months vs. 8 months, 33 months vs. 18 months） with statistical significance（P＜0.05）. Conclusion MTA1 is highly expressed in SCLC tissue， and is closely correlated with tumor metastasis， drug resistance and prognosis.