Abstract: Objective To observe the safety and adverse reactions of the low-dose dexamethasone premedication with paclitaxel chemotherapy， explore a new paclitaxel premedication procedure. Methods Paclitaxel（135-175mg/m2） combined with platinum drugs was used in 151 patients， 21 days was a cycle. Two kinds of the premedication procedure be used before injection of paclitaxel， one in standard premedication procedure， the other in low-dose dexamethasone premedication procedure， observe the drug safety and adverse reactions. Results Paclitaxel chemotherapy in 75 cases of low-dose dexamethasone premedication and 76 cases of standards with acute allergy rates were 8.0％ and 9.2％； peripheral neuritis rate were 38.7％ and 40.8％， muscle and joint pain rate were 52.0％， 53.9％. There was no statistically significant between the two groups. Conclusion There was no difference in acute allergic reaction of paclitaxel chemotherapy before the application of Low-dose dexamethasone premedication compared with standards.