Abstract: Objective To study the clinical value and complications of ultrasoundguided lung biopsy in diagnosis of peripheral pulmonary masses. Methods One hundred and seventy-three cases with peripheral pulmonary masses were enrolled and directly applied percutaneous lung biopsy using needle aspiration under ultrasound guiding after examining. Biopsy samples were performed by cytology and histopathological examination. Results Successful procedures were performed in all cases. Masses were found by both cytological and histological examination with diagnostic accuracy rate of 96.0％（166／173）. Biopsyrelated complications occurred in 22 patients， including blooding in 9 patients（5.2％）and pneumothorax in 13（7.5％）. Conclusion Ultrasound-guided percutaneous peripheral pulmonary lesions biopsy is a safe and effective tool in the diagnosis and management of peripheral pulmonary disease.