Abstract: Objective To describe and summarize the clinical experience with retroperitoneal laparoscopic adrenalectomy to huge adrenal tumors. Methods The clinical data of 32 cases with adrenal tumors ≥6cm in size who had a retroperitoneal laparoscopic adrenalectomy between Jun. 2007 and Mar. 2013 were reviewed retrospectively.Results All the operation were successful. The average operation time was 80min（45 to 110min）， the average intraoperative blood loss was 80ml（30 to 180ml）. The follow up for all cases ranged from 3 to 50 months（average 19.5 months）, 1 patient died of recurrence. Conclusion Retroperitoneal laparoscopic adrenalectomy for huge adrenal tumor is technically feasible and safe. Tumor size was not the determinants of laparoscopic resection of adrenal tumor. Priority blocking adrenal central vein could effectively reduce intraoperative bleeding volume and sudden functional tumor symptoms.