Abstract: ObjectiveTo explore the characteristics of episodic memory impairment of breast cancer patients with chemotherapy-induced cognitive impairment. Methods Forty female patients with breast cancer undergoing 6-cycle adjuvant chemotherapy were enrolled in this study. The neuropsychological background was evaluated by mini-mental state examination （MMSE）， verbal fluency test （VFT） and digit span （DS） before and after chemotherapy. Meanwhile， the source memory and item memory situation were measured using source memory and memory neuropsychological test before and after chemotherapy. Results There was no significant difference on MMSE，VFT and DS before and after chemotherapy （P＞0.05）. The scores of item memory were 0.69±0.06 and 0.66±0.08 without significant difference （P＞0.05）. The score of source memory was 0.51±0.08 after chemotherapy， lower than 0.70±0.06 before chemotherapy with significant difference （P＜0.05）. Conclusion These results suggest that breast cancer patients undergoing adjuvant chemotherapy show deficits in episodic memory， mainly on source memory， but little on item memory.