Abstract: Pancreatic carcinoma（PC） is one of the most detrimental common digestive malignancies， which is characterized by hidden onset， rapid progression and short course. Chemotherapy is an indispensable treatment approaches for patients with advanced PC. Gemcitabine act as a gold standard drug， but its effect is limited. A new drug， that is Nab-paclitaxel with its unique formulation advantage， has made breakthrough progress in the treatment of advanced PC and has become the new standard chemotherapy drugs for advanced pancreatic carcinoma.