Abstract: Most of the genome are non-coding regions， from which the non-coding RNAs（ncRNA） are transcribed. These ncRNAs may play vital roles in tumorigenesis by regulating oncogene and tumor suppressor gene at either epigenetic level or post-transcriptional level， and act as potential targets for tumor diagnosis， prognosis and therapy. MicroRNA（miRNA） and long non-coding RNA（lncRNA） are two important subspecies of ncRNA. LncRNAs play biological roles through a variety of mechanisms， including genetic imprinting， chromatin remodeling， cell cycle control， splicing regulation， mRNA decay and translational regulation. Recently， the interaction between miRNA and lncRNA in the development and progression of cancer has drawn the attention of many researchers. This review focuses on the interaction between these two RNAs and its studying methods.