Abstract:

Objective To analyze prognosis-related factors of the non-small lung cancer（NSCLC） patients with bone metastasis as an initial presentation.
Methods In the retrospective study， 46 NSCLC patients with bone metastasis as an initial presentation from Anhui Provincial Hospital Affiliated to Anhui Medical University and Anhui Provincial Cancer Hospital between February 2010 and February 2012 were investigated. The KaplanMeier method was employed to evaluate survival. Then the median overall survival（OS） was analyzed among different clinicopathological parameters， including age， sex， smoking， pathological type， the number of bone metastasis， bone related events， other parts of the transfer， ECOG score， alkaline phosphatase and carcinoembryonic antigen. The Cox multivariate analysis was used to evaluate the independent factors affecting survival of patients. Results The median OS of 46 NSCLC patients was 237 days. The univariate analysis showed that tumor subtype， number of bone metastasis and ECOG performance status were prognostic factors. Multivariate analysis showed that the independent predictors of OS were tumor subtype（OR=2.996， 95％CI： 1.070-8.389， P=0.037） and the number of bone metastasis（OR=3.263， 95％CI： 1.083-9.827， P=0.036）. Conclusion Tumor subtype and the number of bone metastasis of NSCLC patients with bone metastasis as an initial presentation may be independent prognosis predictors.