Abstract: Incidence of gastric cancer accounted for the fourth in global cancer incidence， and the mortality accounted for the second. Most patients bearing gastric cancer are already advanced and unresectable at the time of diagnosis. Chemotherapy and molecular targeted therapy have been more and more emphasised on clinical research and practice as an effective means of treatment of gastric cancer. In recent years， the targeted therapy of epidermal growth factor receptor（EGFR） family has achieved fruitful results in the treatment of gastric cancer. This article summarizes the signal transduction mechanisms of EGFR family and associated targeted drugs in the treatment of gastric cancer.