Abstract: Signet ring cell carcinoma（SCC） is a special form of adenocarcinoma with a large vacuole full of mucin displacing the nucleus to the periphery. The frequency of gastric signet ring cell carcinoma is about 3.4％-39％. With the characteristics of high degree of malignancy， poor differentiation， intramural diffuse infiltrative growth and rapid progression， the prognosis of SCC is quite poor. It is also resistant to chemotherapy and radiotherapy. Recently， it has been found that SCC has certain biological characteristics which differs it from other type adenocarcinoma. Those biological characteristics can be potential biomarkers and targets for therapy. In the current review， we summarize the clinicopathological and biological characteristics of SCC， which may aim at the therapy of it.