Abstract: Objective To investigate the relationship between single nucleotide polymorphism（SNP） of rs4779584， rs4444235 and the susceptibility of colorectal cancer（CRC） in Taizhou area of Jiangsu province. Methods This hospital-based case-control study was conducted in 160 cases with CRC and 170 healthy controls. The association between the rs4779584，rs4444235 polymorphism and CRC was examined by the overall odds ratio with a 95% confidence interval.
Results Genotype distribution of rs4779584 C/T and rs4444235 T/C was in accordance with Hardy-Weinberg balance in both groups. Compared with the control group， the distribution of genotype and allele of two SNPs were statistically significant in disease group（P<0.05）. In rs4779584 C/T， when the CC genotype was used as the reference， the CT/TT genotypes were associated with the risk for CRC； when the CC/CT were used as the reference， the TT genotype was associated with the risk for CRC； when C allele was used as the reference， the T allele was associated with the risk for CRC（P<0.05）. In rs4444235 T/C， when the TT or TT/TC were used as the reference， the CC genotype was associated with the risk for CRC； when T allele was used as the reference， C allele was associated with the risk for CRC（P<0.05）.
Conclusion Carriers of TT homozygous or T allele at rs4779584 and CC homozygous or C allele at rs4444235 had increased susceptibility to development of CRC in Taizhou area of Jiangsu.