Abstract: Objective To explore the independent prognosis factors of long-term survival for patients of gastric carcinoma with malignant ascites. Methods From December 2011 to October 2013， 58 gastric cancer patients with malignant ascites receiving treatment in Xijing Hospital were included in this study. Survival analysis was performed using Kaplan-Meier method. Univariate analysis of prognosis was made by Log-rank method. Multivariable analysis of prognosis was used by Cox proportional hazad regression model. Results The median overall survival was 14.0 months. In univariate analysis， degree of differentiation， depth of invasion， liver metastasis， KPS score and therapeutic method correlated with the prognosis of the patients of gastric carcinoma with malignant ascites. Multivariate analysis revealed that degree of differentiation， depth of invasion， liver metastasis， KPS score and therapeutic method were independent risk factors of prognosis. Conclusion Degree of differentiation， depth of invasion， liver metastasis， KPS score and therapeutic method may serve as strong factors with gastric carcinoma. Dependent prognostic factors can guide the choice and practice of the therapy for gastric carcinoma with malignant ascites.