Abstract: Objective To investigate the expression of hedgehog signaling pathway related protein Gli1 in breast cancer and its clinical significance.
Methods The immunohistochemical method was used to detect the expression of Gli1 in 102 cases of breast invasive ductal carcinoma and 30 cases of corresponding adjacent normal breast tissues， and then its relationship with clinicopathological features were analyzed. Results The positive expression rate of Gli1 in breast cancer tissues was 75.5％ （77／102）， higher than 26.7％ （8／30） of paired adjacent normal tissues， with significant difference （P＜0.05）.The expression of Gli1 was related with axillary lymph node metastases， estrogen receopter， but not related with age， postmenopause， tumor size， pathological stage， histological grade， progesterone receptor and human epidermal growth factor receptor 2（P＞0.05）. Conclusion Hedgehog signaling pathway related protein Gli1 is high expression in breast cancer tissues and it have some effect of negative regulation on estrogen receptor.