临床肿瘤学杂志

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非小细胞肺癌T细胞CTLA-4免疫靶向治疗基础与转化性研究现状的思考

余宗阳1,莫享阳2,欧阳学农1
  

  1. 1 350025 福州 南京军区福州总医院肿瘤科 2 350108 福建中医药大学研究生院
  • 收稿日期:2014-09-22 修回日期:2014-11-27 出版日期:2015-04-30 发布日期:2015-04-30

CTLA-4 T cells immune targeted therapy based and status of transformation research in non-small cell lung cancer

YU Zongyang, MO Xiangyang, OUYANG Xuenong.   

  1. Department of Medical Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025,China
  • Received:2014-09-22 Revised:2014-11-27 Online:2015-04-30 Published:2015-04-30

摘要: 细胞毒T淋巴细胞相关抗原4(CTLA-4)是一种白细胞分化抗原,参与免疫反应的负调节。随着非小细胞肺癌(NSCLC)的治疗模式由驱动基因靶向治疗向免疫靶向治疗的转变,CDLA-4已成为一个新的研究热点。本文梳理近年来CTLA-4在NSCLC领域的研究情况,并结合相关基础及临床转化性研究进展作一综述。

Abstract: Cytotoxic T lymphocyte associated(CTLA-4) is a kind of leukocyte differentiation antigens, it participates in the negative regulation of immune response. As the treatment of non-small cell lung cancer (NSCLC) model by the driver gene targeted therapy to immune targeted therapy,CDLA-4 has become a new research hotspot. This article combing CDLA-4 research of NSCLC in recent years and reviews the connecting with the related basic and clinical research progress.

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