Abstract: Objective To investigate the expression of fibroblast growth factor-inducible 14（Fn14）in esophageal carcinoma and its relationship with clinical data and prognosis of patients with esophageal squamous cell carcinoma（ESCC）. Methods In this study， Fn14 expression in tumor tissues was assessed using immunohistochemical（IHC）methods in 118 patients with resected ESCC. The association of Fn14 expression with clinicopathological parameters were also evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of Fn14 expression on survival. Results It showed that Fn14 was expressed in 51.7% （61/118） and 4.2% （5/118） of cancer lesions and corresponding adjacent non-cancerous tissue， respectively （P＜0.001）. Fn14 expression was significantly correlated with lymphatic metastasis and TNM stage（P＜0.001）. The median overall survival of Fn14 positive expression patients and negative expression patients were 23 months（95%CI：17-29 months） and 54 months（95%CI：50-58 months） with statistical significance （P＜0.001）. Multivariate analysis indicated that in addition to the T and N stage， Fn14 expression may also be an independent prognostic factor in ESCC （HR=1.51， 95%CI：1.02-2.24， P=0.022）. Conclusion Fn14 expression is of clinical significance and can serve as a prognostic biomarker in ESCC.