Abstract:

Kruppel-like factor 4（Klf4），a zinc finger-type protein transcription factor，plays an important role in the cell growth， apoptosis， proliferation and differentiation by regulating the expression of a number of downstream target genes. Klf4 is a transcription factor which functions as a tumor suppressor and oncogene. This article summarizes the structure of Klf4， biological function and latest research progress in digestive system neoplasms.