Abstract: Objective To investigate the clinical efficacy of recombinant human granulocyte colonystimulating factor（rhGCSF） collutory on chemotherapyinduced oral ulcer. Methods Fifty cases of malignant tumors patients were divided into control group and observation group with 25 cases in each group according to random number table.The control group was treated by Bingpeng powder，Xilei powder plus 100 ml normal saline with gargling administration（10 ml each time， 3-5 times daily， 3 min for each gargling）and the observation group was treated by mouthwash containing 100 ml normal saline， rhG-CSF 100 μg， dexa-methasone 5 mg， lidocaine 10 ml，gentamicin 160 thousand unit， Bingpeng powder and Xilei powder with the same usage and dosage of control group. Two groups were given mouthwash from the occurrence of oral ulcer within 24 hours until oral ulcer healing or completing 7 days of mouth rinse. The overall response rate of oral ulcer healing， remission rate of pain， the time of alleviating pain and the average healing time of oral ulcer were observed and recorded.
ResultsIn observation group， the response rate of oral ulcer healing was 92.0％， while in control group it was only 60.0％ with statistic significance（P＜0.05）. The pain remission rate of observation group was 84.0％，which was significantly superior to that of the control group（52.0％） with significant difference（P＜0.05）. After treatment， the pain scores （VAS） of observation group improved more than that of control group at different time points（P＜0.05）.The average healing time of oral ulcer in observation group was significantly shorter than that of control group［（3.5±1.2） d vs.（5.7±1.3） d，P＜0.05］. Conclusion The efficacy of rhG-CSF collutory on treating chemotherapyinduced oral ulcer is satisfactory. It can effectively reduce the severities of oral pain and the time of alleviating pain，improve oral ulcer healing，and obviously shorten the healing time of oral ulcer.