Abstract: Hypoxia has been a common peculiarity of solid tumor and played a crucial role in tumor microenvironment. More and more evidences have shown that the tumors biological behavior，to large extent，is influenced by microenvironment.The cancer cells adapt to the micro environment by regulating the hypoxia inducible factors（HIFs）. Microenvironment hypoxia accelerates the formation of cancer stem cells（CSCs），circulating tumor cells（CTCs）， and induces epithelialmesenchymal transition（EMT）. Besides it increases the possibility of invasion， metastasis and drug resistance of the tumor. Improving the hypoxia tumor microenvironment can impede the occurrance and development of the tumor.