Abstract: Objective To evaluate the value of contrast-enhanced ultrasound （CEUS） and ultrasonic elastography （UE） in differentiating diagnosis of breast malignant lesions from benign. Methods Eighty-two patients with 96 breast lesions were underwent CEUS and UE. All cases were proved by surgical pathology.The sensitivity， specificity and diagnostic rates of CEUS and UE were evaluated. Results There were 57 benign lesions and 39 malignant lesions among 96 breast nodules confirmed by pathohistology. CEUS showed that the malignant group presented with longer arrival time and peak time， stronger peak intensity， and shorter fade time compared with benign lesions（P＜0.05）. UE showed that the malignant lesions were mainly in score 4 or strain ratio（SR）≥3.03， while the benign lesions were in score 1-2 or SR＜3.03. The sensitivity， specificity， and diagnostic rates of CEUS and UE were 71.8%，89.5%，82.3% and 82.1%，86.0%，84.4%. The sensitivity，specificity and diagnostic rates of UE combined with CEUS were 94.9%， 96.5% and 95.8%. The difference had statistical significance compared with CEUS and UE（P＜0.05）. Conclusion Both CEUS and UE have high value in differentiating diagnosis of breast malignant lesions from benign，and the combination of the two methods can improve diagnostic rates.