Abstract:

Collective invasion is one of the main movement styles of tumor cells. The roles of the collective migration of tumor cells in invasion and metastasis are attracting attention. Collective migration is the important movement pattern in the embryos development. Similarly， accumulating evidence suggests that the collective invasion is common style in malignancies. The potential mechanisms that collective invasion participates into spreading and metastasis of tumor cells are being revealed. The intensive research on collective cell invasion of cancer cells may be helpful to find the new therapeutic method for suppressing invasion and metastasis.