Abstract: Objective To observe the shortterm efficacy of relieving the airway obstruction in patients with local advanced lung cancer by intratracheal radiotherapy combined with external irradiation. Methods During August 2013 to October 2015， 31 local advanced lung cancer patients with airway obstruction were undergone intratracheal radiotherapy（5 Gy/f×23 f） and simultaneously received external irradiation with DT （intratracheal radiotherapy+external irradiation） of 65 Gy. Clinical efficacy was evaluated by Canadian Medical Research Council （MRC） dyspnea scale and the degree of airway stenosis. Results All patients with airway obstruction revealed better efficacy in dyspnea and airway stenosis classification after treatment（P<0.01）. Among them， the MRC grade was found lower than 2 in 28 cases， and the degree of airway stenosis was found lower than 1 in 24 cases. The main adverse events were slight haemoptysis （2 cases）， tracheal mucosa edema （1 case），≥grade 2 pneumonitis （9 cases） and ≥grade 2 esophagitis （5 cases）. In this study, 28 of 31 patients were followed up for 3 months （1 death case and 2 cases were lost） and no recurrent airway stenosis was observed. Conclusion Intratracheal radiotherapy combined with external irradiation can efficiently treat the tumorous airway obstruction.