Abstract: Long noncoding RNAs（lncRNAs）refer to noncoding RNA molecules with the length between 200-100 000 nucleotides. They were considered as transcriptional‘noise’without biological function. However，recent studies show that lncRNAs have a wide participation in gene silencing，transcriptional activation，cell cycle and differentiation，chromosome configuration modification，and many other biological functions，making lncRNAs a new hot spot in the field of cancer research. In this review，we give a systematic description of the relationship between lncRNAs and breast cancer carcinogenesis，progression，molecular subtyping，treatment resistance，epithelialmesenchymal transition and exosomes. We hope that this review will help to promote a better understanding of the sophisticated molecular regulation mechanisms of lncRNAs in breast cancer development and pioneer new ideas for diagnostic methods and specific therapeutic targets for breast cancer.