Abstract: Objective To investigate the expression of human leukocyte antigen F-associated transcript 10 （FAT10） and nuclear factor κB p50（NF-κB p50） in infiltrating ductal carcinoma of breast， and their relationship with clinicopathological characteristics.
MethodsFAT10 and NF-κB p50 expression in 112 patients with infiltrating ductal carcinoma of breast and in 53 breast noncancerous tissues were measured by immunohistochemistry. The relationship between FAT10， NF-κB p50 expression and clinicopathological features of infiltrating ductal carcinoma of breast were analyzed.
ResultsThe positive rate of FAT10 and NF-κB p50 expression in infiltrating ductal carcinoma of breast was 77.68％（87/112） and 81.25％（91/112） respectively， significantly higher than 39.62％（21／53）and 45.28％（24／53）in the noncancerous tissues，and the difference was statistically significant （P＜0.001）. The expression of FAT10， NF-κB p50 was related to lymph node metastasis， distant metastasis and TNM stages of infiltrating ductal carcinoma of breast（P＜0.05）. But they had no obvious relation to age， tumor size and molecular type（P＞0.05）. The expression of FAT10 was positively correlated with the expression of NF-κB p50（r=0.624，P＜0.001）.
ConclusionThe expression of FAT10， NF-κB p50 is closely associated with malignancy and invasive metastasis of infiltrating ductal carcinoma of breast. They may together promote tumor's occurrence and development.