Abstract: Objective To evaluate the longterm survival outcomes and prognostic factors of locoregionally advanced （Ⅲ, ⅣA, ⅣB） nasopharyngeal carcinoma（NPC） patients treated with intensitymodulated radiation therapy （IMRT） plus chemotherapy in Jiangsu Province. Methods From January 2009 to December 2013， 635 locoregionally advanced NPC patients treated by IMRT and platinumbased chemotherapy were analyzed retrospectively. Survival data were calculated with a KaplanMeier method. Logrank test and Cox proportional hazard regression model were performed to investigate the risk factors of prognosis. Results With a median follow-up of 63.5 months （range 5.92 months）， the 5-year local recurrence-free survival （LRFS）， regional recurrence-free survival （RRFS）， distant metastasisfree survival （DMFS）， diseasefree survival （DFS） and overall survival （OS） rates were 88.4％， 94.2％， 79.2％， 71.9% and 76.3％， respectively. Of the 635 patients， 175 （276％） developed failure after treatment. Distant metastasis （n=131, 749％） was the major failure pattern after treatment. T stage was an independent prognostic factor for LRFS. N stage， clinical stage and chemotherapy were independent prognostic factors for RRFS， DMFS， DFS and OS. Conclusion IMRT provides satisfactory longterm outcome for NPC. T and N stage are important prognostic factors， as well as chemotherapy.