Abstract: Exosomes are derived from multivesicular bodies which fuse with cell membrane and then release the exosomes into extracellular space，ranging 20-100 nm in diameter.Exosoomes comprise protein，nucleic acids，lipids and many other bioactive molecules.The transfer of secreted molecules to target cells can mediate intercellular communication and alter the functional status of target cells. It is found that the role of exosomes in the development，diagnosis and treatment，drug resisitance of colon cancer is crucial.This review mainly summarizes the current advances in colon cancer，clarifying the role of exosomes in the diagnosis, occurence and development, treatment and drug resistance of colon cancer.