Abstract: Metastasisassociated lung adenocarcinoma transcript 1（MALAT1），as one of long non-coding RNAs（lncRNAs），is verified to be high expressed in various tumors such as non-small cell lung cancer，breast cancer，cervical cancer，bladder cancer and etc. It plays a significant role of oncogene and is closely related to the development and progression of tumors. It is likely to be regarded as a target for diagnosis, treatment and prognostic prediction in tumors. This review summaries the latest domestic and overseas studies to state the mechanisms of MALAT1 in various tumors.