Abstract: Prostaglandin E2 （PGE2） has been proposed as an important cellular factor associated with hepatic cancer cell growth and invasion. PGE2 regulates tumor development and progression by combining with E prostanoid receptors （EP receptors） on the surface of the cell membrane. PGE2 exerts its effects by upregulating the expression of key molecules including survivin and YB-1， in hepatic cancer cells. PGE2 regulates survivin expression through EP1／EGFR／PI3K／Akt signaling pathway， and YB-1 expression through EP1／Src／EGFR／p44／42 MAPK／mTOR signaling pathway. In this review， we discuss the mechanism of prostaglandin E2 promoting hepatic cancer cell growth and invasion via receptor EP1， which may represent a new therapeutic strategy for the prevention and treatment of hepatic cancer.