Abstract: Objective To investigate the association between coagulation detection and tumor invasion， nodal status， staging in patients with gastric cancer. Methods From Jan 2014 to Nov 2014，a total of 120 patients with gastric cancer as the experimental group and 60 healthy volunteers as control were enrolled to receive coagulation index detection. The test items included prothrombin time （PT）， activated partial clotting enzyme live time （APTT）， thrombin time （TT）， fibrinogen （Fib）， D-dimer （DD） and platelet （PLT）.We compared the difference of the blood coagulation indexes of both groups and analyzed the correlation between these blood coagulation indexes and the depth of tumor invasion， lymph node metastasis， and clinical staging. Results Compared with control group， Fib， DD and PLT were significantly higher in gastric cancer group with statistical significant （P＜0.05）， while APTT， TT and PT were not significantly different between both group （P＞0.05）. In gastric cancer patients， T2-T4 staging compared to T1 staging， N1-N3 staging compared to N0 staging， and Ⅳ staging compared to Ⅰ-Ⅲ staging， Fib， D-D， PLT were significantly elevated with statistical difference （P＜0.05）. Conclusion Compared with the healthy volunteers， blood coagulation function of patients with gastric cancer significantly deteriorated. The blood coagulation function is closely related to the depth of tumor invasion， clinical staging and lymph node metastasis.