Abstract: Objective To explore the clinical value of contract enhanced ultrasound （CEUS） and elastography in the diagnosis of thyroid carcinoma. Methods From March 2014 to December 2015， 168 lesions of 139 patients with thyroid nodes were enrolled and divided into three groups according to the testing means. There were CEUS group of 52 patients with 66 thyroid nodes， elastography group of 56 patients with 68 thyroid nodes and CEUS combine with elastography group of 31 patients with 34 thyroid nodes. All thyroid node lesions were confirmed via needle aspiration biopsy. The pathology， routine color Doppler ultrasound findings and imaging findings of each group were analyzed， and the efficacy of each group in the diagnosis of thyroid cancer was analyzed by receiver operating characteristic curve （ROC）. Results One hundred and sixty-eight thyroid nodes （including 109 benign and 59 malignant lesions） of 139 patients were confirmed by pathology. In CEUS group， 41 benign and 25 malignant thyroid nodes were diagnosed. In elastography group， 47 benign and 21 malignant thyroid nodes were diagnosed. In CEUS combine with elastography group， 24 benign and 10 malignant thyroid nodes were diagnosed. The ROC curve area of benign and malignant thyroid nodes by the CEUS combine with elastography groups， elastography， CEUS diagnosed were 0.924， 0.883， 0.847 respectively. The sensitivity， specificity and accuracy by the CEUS combine with elastography groups， elastography， CEUS diagnosed were 70.0％， 75.0％， 73.0％； 96.8％， 94.4％， 94.6％ and 90.0％， 77.7％， 80.0％. The diagnostic efficacy of CEUS combined with elastography is superior to that of elastography and CEUS alone. Conclusion CEUS combine with elastography can obviously improve the diagnosis accuracy of thyroid carcinoma. It has good clinical value in clinic.