关键词: 宫颈癌, CT灌注参数, 放射治疗, 敏感性

Abstract: ObjectiveTo evaluate the value of CT perfusion parameters on the radiotherapy sensitivity of cervical cancer. 
MethodsFrom February 2014 to July 2016， 120 patients with cervical cancer were enrolled. All the patients were given CT perfusion scanning to caculate the related parameters including blood flow（BF）, blood volume（BV）, mean transit time （MTT） and permeability surface（PS） and intensity modulated radiation therapy. The pelvic irradiation was 1820 Gy／f， 56 times／week， and the total dose was 4045 Gy. The curafive effect was evaluated after 4 weeks of radiotherapy. Factors influencing radiotherapy sensitivity were analyzed by Logistic regression model. 
ResultsOne hundred and twenty patients were completed the radiotherapy. There were complete remission in 34 patients， partial remission in 46 patients， stable disease in 20 patients and disease progression in 20 patients. The radiotherapy sensitivity was 667％（80/120）. Age， body mass index， tumor size， pathological type， FIGO staging and differentiation had no difference between sensitive group and insensitive group （P＞005）. But lymph node metastasis had difference between the two groups （P＜005）. The value of BF in sensitive group was significantly lower than that of insensitive group［（5922±1630）ml／（min·100 g） vs.（7204±1294）ml／（min·100 g）］， while the values of BV［（1214±281）ml／100 g vs.（568±193）ml／100 g］， MTT［（1172±448）s vs.（1034±622）s］ and PS［（2056±852）ml／（min·100 g） vs.（910±184）ml／（min·100 g）］ were significantly higher than those in insensitive group （P＜005）. Logistic regression analysis showed that BV was independent factor influencing radiotherapy sensitivity （P＜005）. 
ConclusionCT perfusion parameters of cervical cancer can evaluate and reflect radiotherapy sensitivity. BV is the main factor influencing radiotherapy sensitivity.

Key words: Cervical cancer, CT perfusion parameters, Radiotherapy, Sensitivity