Abstract: Objective To investigate the expression of N-myc down stream regulated gene 1（NDRG1） in breast carcinoma tissues and the relations with ER， PR， p53， c-erb-B2. Methods The expressions of NDRG1，ER，PR， p53 and c-erb-B2 proteins were detected in 82 breast carcinoma samples by immunohistochemical staining， then the correlation of their expression was analyzed. The relationship between clinical characteristics and NDRG1 expression was also studied. Results The positive rate of NDRG1 protein expression was higher in early stage breast cancer than that in advanced breast cancer（P=0.014）. NDRG1 protein expression has significantly negative correlation with p53（r=-0.233， P=0.035）， but no association could be detected among NDRG1，ER， PR and c-erb-B2（P＞0.05）. Conclusion NDRG1 plays an important inhibition role in the development of breast cancer，and it may be considered as a valuabe marker for the gene research and therapy of breast carcinoma.