Abstract: Objective To evaluate the efficacy and toxicity of oxaliplatin plus gemcitabine in the treatment of advanced biliary tract carcinoma.
Methods Thirtyeight patients with advanced biliary tract carcinoma diagnosed by imageology and histopathology were treated with oxaliplatin 85 mg/m² iv 2h, d₁, gemcitabine 835 mg/m² iv 30min, d₁ and d₈. The regimen was repeated every 21 days and at least two cycles. The evaluation was performed after the chemotherapy for two cycles.
ResultsThirty-eight patients were evaluable for objective response rate. Complete remission (CR) was observed in 1 case and PR in 7 cases, and the objective response rate was 21.1 % (8/38).The main side-effects were myelosuppression, neuro-sensory toxicity and nausea /vomiting. There were no any death events during treatment.
Conclusion Oxaliplatin plus gemcitabine in the treatment of advanced biliary tract carcinoma is effective and tolerable. It is worth of studying in the future.