Abstract:

Objective To investigate the expression of hypoxiainducible factor-1α（HIF-1α） in nonsmall cell lung cancer（NSCLC）and its relationship with clinicopathological feature with a systematic review. Methods Studies assessing clinical significance of HIF-1α expression in NSCLC published until April 2012 were selected on the basis of Pubmed，EMBASE，Cochrane Library，and CNKI. The meta analysis in this study was performed by the statistical software STATA 11.0.A meta analysis was performed to clarify the impact of HIF-1α expression on clinicopathological in NSCLC. Results A total of 19 studies were recruited. As for the positive rate of HIF-1α expression，significant differences were tested between NSCLC and normal lung tissues（OR=35.55，95％CI: 18.79-67.25，P=0.000）. There was no significant differences between T stages T3-T4 and T stages T1-T2（OR=2.50，95％CI:0.89-6.97，P=0.081）. There were significant differences between low differentiation and medium-and high-differentiation（OR=1.81，95％CI:1.11-2.98，P＜0.05），lymph node metastasis and non-lymph node metastasis（OR=2.97，95％CI:1.84-4.80，P＜0.05），and clinic stages Ⅲ-Ⅳ and clinic stagesⅠ-Ⅱ（OR=2.56，95％CI:1.58-4.15，P＜0.05）. Conclusion HIF-1α may play an important role in NSCLC，and the overexpression of HIF-1α correlates with malignant biological behavior.