Chinese Clinical Oncology

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Transanal local excision of T2 low rectal cancer after irinotecan chemotherapy combined shortterm radiotherapy

WANG Wen-da,LIANG Xiao-bo,LU Yan-jun,LIU Dong-bo,WANG Li-chun   

  1. Department of Colorectal Surgery, Shanxi Tumor Hospital
  • Received:2012-07-04 Revised:2012-09-16 Online:2012-12-31 Published:2012-12-31
  • Contact: LIANG Xiao-bo

Abstract:

Objective To investigate the feasibility of transanal local excision of T2 rectal cancer after irinotecan chemotherapy combined shortterm radiotherapy.
MethodsThirtyseven patients with T2 rectal cancer who underwent irinotecan chemotherapy combined shortterm radiotherapy followed by transanal local excision from Jan. 2002 to
Aug. 2008, were reviewed.
ResultsUnderwent preoperative treatment,complete responses and partial responses were achieved in 4(10.8%)and 27(73.0%)patients, respectively. Six patients were stable
disease and no one occurred disease progress. The response rate was 83.8% and disease control rate was 100.0%. Four patients underwent postoperative complications, 2 patients(5.4%) were anal stenosis, 1 patient(2.7%) were bleeding and 1 patient(2.7%) were rectovaginal fistula.A total of six patients(16.2%)postoperative recurrence and metastasis,3 patient were local recurrence, 2 patients were liver metastases,1 patient was local recurrence with liver metastasis. 3, 5year recurrence rates were 11.7% and 14.1%,respectively. Three patients died of metastasis and recurrence. 3, 5-year overall survival were 94.6% and 91.4%,respectively. ConclusionFor appropriate patients of T2 rectal cancer,transanal local excision after irinotecan chemotherapy combined shortterm radiotherapy can be used as the clinical choice.

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