Abstract: Objective To investigate the objective efficacy， survival benefit, safety and the importance of preservation of the larynx organ functional in Chinese patients with laryngeal carcinoma by different means of treatment.
MethodsThe data of 92 cases of laryngeal cancer patients treated in 81 Hospital of PLA from January 2000 to May 2012 were analyzed retrospectively. All patients were divided into chemoradiotherapy group， surgical treatment group and the operation combined with chemoradiotherapy group. The treatment， survival time and the quality of life（QOL） of different treatment groups were compared and analyzed.
ResultsNinetytwo cases of laryngeal cancer patients with chemoradiotherapy group in 39 cases， 20 cases in surgical treatment group， 33 cases in the operation combined with chemoradiotherapy group. The 12 patients of stage Ⅳ in chemoradiotherapy group received PF regimen， NP／NF regimen， paclitaxelbased chemotherapy and Chinese medicine Fufang Hongdoushan capsule combined with radiotherapy of throat or cetuximab treatment. Of 12 patients in stage Ⅳ， One patient achieved CR， with PR in 3 cases， SD in 6 cases， PD in 2 cases. The response rate（RR） was 33.3％（4／12） and the disease control rate（DCR） was 83.3％（10／12）. QOL was improved in 7 cases， stable in 4 cases， only 1 case of deterioration. Improvement and the stable rate was 916％. The main toxicity of chemotherapy and radiotherapy in 12 patients were grade 3 of nausea and vomiting in 1 case， grade 3 of leucopenia in 3 cases， grade 3 of thrombocytopenia in 1 case. There were no grade 4 toxicity reaction. By KaplanMeier method， the median overall survival time of 92 patients with laryngeal carcinoma was 60 months. The median overall survival time was 72 months in the chemoradiotherapy group, 90 months in the surgical treatment group and 58 months in the operation combined with chemoradiotherapy group. There were no statistical differences among the three groups（P＞0.05）. Fiftythree of operation patients had obvious pronunciation dysfunction， even lost the pronunciation function， needed permanent tracheostomy and quality of life was reduced. Conclusion Chemotherapy or combined with molecular targeted drugs in the treatment of laryngeal cancer has a good efficacy and toxicity can be tolerated. For a considerable part of the patients， it can replace operation， or reduce the scope of operation and the damage.