Chinese Clinical Oncology

• 论著 • Previous Articles     Next Articles

Predictive value of MITF gene amplification in metastatic melanoma patients receiving recombined human endostatin and dacarbazine as first-line treatment

MA Jiafang, KONG Yan, CUI Chuanliang, LIANG Long, ZHANG Qiannan, TANG Bixia, DAI Jie, GUO Jun.   

  1. Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing 100142, China
  • Received:2013-04-09 Revised:2013-04-24 Online:2013-06-30 Published:2013-06-30
  • Contact: GUO Jun

Abstract: Objective To investigate the predictive effect of microphthalmiaassociated transcription factor(MITF) gene amplification on clinical outcome of recombined human endostatin(endostar) plus dacarbazine as firstline treatment for patients with metastatic melanoma. Methods MITF gene amplification in tumor tissues obtained from 60 metastatic melanoma patients were determined by quantitative real-time PCR. All the patients were followed for disease control rate and long-term efficacy. Results Of 60 tumor tissues, 56 were evaluable for MITF gene detection. MITF gene amplification was detected in 29 of 56 patients(51.8%), 31.2%(5/16) of acral, 63.2%(12/19) of non-acral, 80.0%(8/10) of mucosal and 36.4%(4/11) of unknown primary melanoma(P=0.050). The disease control rate of patients with or without MITF gene amplification were 586% and 81.5%(P=0.063); and the median time to progression were 6.4 months(95%CI:0.5-12.2 months) and 8.4 months(95%CI:6.8-10.3 months),respectively(P=0.169). Conclusion MITF gene amplification rate of Chinese metastatic melanoma is high. It seems to have potential to predict the efficacy of endostar plus dacarbazine in treatment of metastatic melanoma. Further survival data needs long-term follow-up.

No related articles found!
Viewed
Full text
252
HTML PDF
Just accepted Online first Issue Just accepted Online first Issue
0 0 0 0 0 252

  From Others local
  Times 8 244
  Rate 3% 97%

Abstract
89
Just accepted Online first Issue
0 0 89
  From Others
  Times 89
  Rate 100%

Cited

Web of Science  Crossref   ScienceDirect  Search for Citations in Google Scholar >>
 
This page requires you have already subscribed to WoS.
  Shared   
  Discussed   
No Suggested Reading articles found!